MedCalc Software bvba in Belgium designed and developed MedCalc as a complete medical and statistical toolset specifically for biomedical research. The software has a built-in spreadsheet for managing raw data in a database or table format and a WYSIWYG text editor for creating charts or graphs of the statistical results. It can open files created in Excel, Lotus, Dbase, and SPSS. The graphs created in MedCalc may be saved as images in BMP, PNG, GIF, PCX, JPG or TIF format or exported as PPT slideshows. Statisticians and medical researchers often use this tool when running a Receiver Operating Characteristic curve analysis to discriminate among different groups and settings in the study. In addition to the ROC curve, this program also applies statistical analysis methods like the Bland-Altman plot, the Passing and Bablok regression, and the Deming regression when comparing two or more samples.